Stephen G. Matthews is Professor of Physiology, Obstetrics and Gynecology and Medicine at the University of Toronto. He is the Director of Research at the Alliance of Human Development. Professor Matthews received his PhD from the University of Cambridge, UK. He was appointed to the University of Toronto in 1996, and served as Chair of the Department of Physiology 2007-2014.
His research is focused towards understanding how alterations in the fetal environment can affect developmental trajectories leading to modification of neurologic and endocrine function. His recent research has established that the effects of altered fetal environments can extend across multiple generations. With a focus on epigenetics, his research team is determining the molecular mechanisms by which such ‘programming’ can occur. In a parallel program of study, his group is investigating drug and hormone transport mechanisms in the placenta and fetal brain, with a focus on developing novel treatments that modulate drug transport at these two sites, and that ultimately protect the fetus.
Professor Matthews is committed to translating fundamental research. He was founding co-director of the MAVAN program, which follows neurocognitive development in children following adverse early experience, and has been involved in a number of large international clinical trials. He has published over 200 scientific papers/book chapters, is regularly invited to present his work around the world and is involved in a number of international research initiatives.